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The dual agonism of GLP-1 and GIP receptor was achieved by replacing the tryptophan cage of exendin-4 with the C-terminal undecapeptide sequence of oxyntomodulin along with a single amino acid substitution from histidine to tyrosine at the amino terminus of the peptide

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doi:10.1200/JCO.2017.77.4414 Uhelski ACR, Blackford AL, Sheng JY

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CDSCO Advisory on Prescription Medicine Promotion in India CDSCO has recently issued an advisory on the promotion of prescription medicines indicated for obesity and metabolic disorders

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