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BIR has been demonstrated in postmortem studies of patients with PD (34), AD (35), DLB (36), and MSA (37), associated with dopaminergic depletion in the caudate and ventral striatum (14, 38), frontotemporal cortical atrophy (39, 40), and cerebral glucose hypometabolism (41)

In contrast, the AWARD-11 trial for Trulicity showed modest weight loss as a secondary endpoint in type 2 diabetes patients: approximately 6.6 lbs with the 1.5mg dose, 8.4 lbs with 3mg, and 10.1 lbs (about 4.6 kg) with the highest 4.5mg dose at 36 weeks

Last week, the Food and Drug Administration announced that the shortage of Eli Lillys Zepbound was over, though Wegovy remains scarce