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Description
Trials assess weight loss outcomes and medically important safety events
Its introduction into the market reflects a significant stride in diabetes care and obesity treatments, albeit with considerations for severe problems like allergic reactions and financial implications from a payers perspective
The precise mechanism of kidney-protective effects of GLP-1 RAs still remains elusive, but likely include direct kidney actions such as inducing natriuresis through NHE3 inhibition in the proximal tubules, suppressing the intrarenal renin-angiotensin system, ameliorating kidney ischemia/hypoxia [63, 64]
