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In healthy subjects, oral glucose triggers a stronger insulin secretion response than intravenous glucose because of the secretion of incretin from the gastrointestinal tract, known as the incretin effect. Clinically, incretin-based drugs include glucagon-like peptide 1 receptor agonists (GLP-1 RA) (such as liraglutide) and dipeptidyl peptidase 4 inhibitors (DPP-4i) (such as vildagliptin)

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It notably reported increased serious cardiac eventsincluding ventricular tachycardia, worsening HF, and aggravating ischemic heart diseasein the liraglutide group [29]

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