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The mechanism involves changes in sex hormone binding globulin from rapid weight loss, reduced peripheral estrogen production from fat tissue reduction, and hypothalamic-pituitary-ovarian axis response to caloric restriction
In most studies, bariatric surgery produces greater total weight loss and more durable results over time compared to medication alone
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GLP-1 receptors exist throughout the brainstem, including in the area postrema and the nucleus tractus solitarius, two regions that form part of the vomiting reflex circuit
