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An interesting next phase is to try to understand how we get these benefits, because maybe there are ways to further exploit that benefit for even better long-term improvements in graft and patient survival. Severe adverse events were rare, according to the researchers

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Small molecule positive allosteric modulators of the GLP-1 receptor, with or without their own agonist capability, can alter the conformation of the GLP-1 receptor and increase its affinity for GLP-1

Starting low and increasing gradually, ideally with guidance from a clinician or dietitian, can improve tolerability