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GLP-1s and Addiction The authors of GLP-1 Therapeutics and Their Emerging Role in Alcohol and Substance Use Disorders: An Endocrinology Primer , appearing in October 2025 in JES, point out that the World Health Organization reported 890 million adults and 60 million children and adolescents had obesity in 2022 globally

Eventually, individuals on tirzepatide had a low occurrence of end-stage kidney disease, death due to kidney failure, macroalbuminuria, and eGFR decline compared to individuals on insulin glargine [14]

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This 10-week taper is the most conservative option and may be ideal for people who have been on medication for extended periods, 6 months or longer, or who have a significant amount of weight to maintain