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Contraindications Known hypersensitivity to losartan or ARB class Hypersensitive reactions preclude further formulation exposure

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Some genetic profiles respond better to tirzepatide's dual GLP-1/GIP mechanism, while others optimize with semaglutide alone

GIP also stimulates bone formation and inhibits bone resorption [38], but we dont have any clinical evidence to date of an effect on bone preservation with a GLP- 1/GIP dual agonist for weight loss