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Description
The GIP receptor responds first at lower concentrations because tirzepatide has stronger affinity for it

Week 3 of any new dose level GI side effects sometimes peak 1421 days into a new dose before tapering
Life Sci 320:121532 [DOI] [PubMed] [Google Scholar] Al-Kuraishy HM et al (2023f) Evaluation and targeting of amyloid precursor protein (APP)/amyloid beta (A) axis in amyloidogenic and non-amyloidogenic pathways: a time outside the tunnel

Meanwhile, tirzepatide (Zepbound) is specifically approved to address obstructive sleep apnea in adults with obesity