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GLP-1s may help with OA by: Reducing overall inflammation Protecting cartilage in your joints Helping people lose weight takes pressure off the knees and hips Making walking and movement easier over time Studies found that GLP-1 and SGLT2 medicines may lower the risk of needing a knee replacement (for OA), though results varied
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[89] In May 2026, the CHMP adopted a positive opinion, recommending a change to the terms of the marketing authorization for the medicinal product Wegovy

You can learn more in our Overview of GLP1 SideEffects
