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The logical identification of S 1 and S 2 building blocks led to the discovery of effective DPP-2 inhibitors, which were characterized by their high selectivity for DPP-2 over DPP-4

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GIP suppresses macrophage-dependent inflammation, whereas GLP1 reduces gut inflammation through its receptor on intraepithelial lymphocytes

Other genetic loci: Polymorphisms in genes such as CNR1, CTRB1/2 andTCF7L2, have shown associations with GLP-1RA response, particularly liraglutide, affecting glycemic control and metabolic parameters [14,133,135]