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Additionally, research indicates that chronic cold stress can inhibit GLP-1 receptor expression in vital organs like the liver and pancreas

However, some concerns were noted in the domain of deviations from intended interventions, particularly in open-label studies where blinding of participants and personnel was not feasible, which could potentially introduce performance bias

While this is the licensed indication, it's important to note that NICE guidance (TA875) recommends more specific criteria for NHS use: typically for people with a BMI 35 kg/m (lower thresholds may apply for some ethnic groups) with at least one weight-related comorbidity, prescribed within specialist weight management services, and limited to a maximum treatment duration of 2 years

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