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Peptide Vials (Tirzepatide, 30 mg each): 8 weeks (2.55 mg/wk): ~30 mg total 1 vial 12 weeks (2.57.5 mg/wk): ~60 mg total 2 vials 16 weeks (2.510 mg/wk): ~100 mg total 4 vials Insulin Syringes (U100, 1 mL): 8 weeks: 8 syringes (1/week) 12 weeks: 12 syringes (1/week) 16 weeks: 16 syringes (1/week) Bacteriostatic Water (10 mL bottles): Use 3.0 mL per vial for reconstitution

7 At the time of the SURPASS2 study design and conduct, 1 mg was the highest approved dose of semaglutide for the management of patients with T2D who had shown superiority in lowering glucose levels and reducing body weight compared with two selective GLP1 RAs, dulaglutide (0.75 and 1.5 mg) and exenatide (2 mg) once weekly, with a similar safety profile