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GLP-1 receptor agonists and heart failure Heart failure (HF) is a complex and debilitating condition with a substantial global health burden (61)

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GLP1RNature Reviews Drug Discovery * 2014liraglutideGLP-1R2T2D18%2.6%2/35%1/310%5%10%27%11% 20216semaglutide1II0.2mg5211.2%-13.8%3.0mg7.8%15%1/320%III2.4 mg6814.9%2.4% GLP-1RAsGLP-1RGLPR-NPAIII GLP-1ARs GLP-1GIP/poly-agonistsGIPR/GLP-1RII12T2DIINN97090.20.5NN9709III2020NN9709 GIPGLP-1T2DIIIGLP-1R261/310% T2DIII1 mg4029%-51%20%5.7%15-40%9%15% GLP-1RGcgRCotadutideGLP-1R/GcgR54IIbT2Dcotadutide5%15.5%10% LY3437943GIP/GcG/GLP-1T2DI12LY3437943 3 MCR4 1994 2014FDA2018EMA ARCPOMCAgRPPOMCPVNMC4R MC4RMC4RMC4RMC1MC3MC5 MC4R30MC4RLY2112688MC4-NN-0453MK-0493AZD2820 Rhythm PharmaceuticalsMC4RsetmelanotideIIIPOMCLEPR202011FDAPOMCPCSK1LEPR 4 IAPPpramlintideFDATIDT2DAOMs 5 x/aCytoCYT009-GhrQbDIO 6 ATP 2006Spiegelaman2, 4-DNPDNPDNP BAM15 2