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Overall, use of GLP1-RA compared with the use of DPP-4i was not associated with an increased risk of thyroid cancer (pooled weighted HR 0.81, CI 0.591.12)

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Additionally, activation of paraventricular hypothalamic nucleus oxytocin neurons or downstream oxytocin neurons in the parabrachial nucleus (PBN) suppresses noncaloric fluid intake while failing to influence eating (Figure 2) (Ryan et al., 2017)

However, current fluorescent imaging techniques may underestimate brain penetrance, and better techniques will be needed to get a fuller picture of which GLP-1 receptors are reached by systemically administered GLP-1R agonists