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4 A 2025 systematic review examining GLP-1 receptor agonists for depression found that several observational studies showed reduced depressive symptoms in people taking these medications, though results from randomised controlled trials were more mixed

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Sammons MF, Lee ECY (2015) Recent progress in the development of small-molecule glucagon receptor antagonists
[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Tanaka K., Okada Y., Tokutsu A., Tanaka Y
