pros and cons of glp 1 Bariatric Surgery Vs. GLP-1: Which Weight Loss Option Fits You? Who should take them? Pros

127 GCGR knockout is detrimental in mice as 50% did not survive until birth in this study

GLP-1 medications work through several complementary mechanisms: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner, which helps lower blood sugar levels Suppressing glucagon release , thereby reducing hepatic glucose production Slowing gastric emptying , which prolongs satiety and reduces appetite Acting on appetite centres in the brain , leading to reduced caloric intake and weight loss Commonly prescribed GLP-1 receptor agonists available in the UK include semaglutide (Ozempic, Wegovy, Rybelsus [oral form]), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), and exenatide (Byetta, Bydureon)

Inflammation can interfere with the bodys ability to lose weight by disrupting normal metabolic processes, and imbalances in gut bacteria can also play a role

Favorable lean mass preservation (only 21.9% of weight loss from lean mass) is a potential safety/tolerability advantage