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In type 2 diabetes, much of the evidence comes from post hoc analyses of trials that primarily examine the effects of single drugs compared with placebo

To this end, HIF-1 and HNFs have been shown to target DPP-4 expression [35]

There was also a reduction in IL-5, 13, and the number of Th2 cells in the lungs compared to semaglutide treatment, but with respect to IL-33, semaglutide was more powerful as its release is mediated particularly through the agonism of the GLP-1 receptor in which tirzepatide has less affinity

Contact your GP or diabetes team if you experience persistent severe nausea or vomiting, severe abdominal pain, signs of dehydration, hypoglycaemia symptoms, or have concerns about medication effectiveness