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ADA Standards of Care 2025) recommend that patients with type 2 diabetes and atherosclerotic cardiovascular disease (ASCVD) (or high risk) should be on a GLP-1 RA with proven CV benefit (or an SGLT2 inhibitor) as part of their regimen, independent of A1c, because of the outcome benefits ( [9] ) ( [144] )

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Alternative diabetes or weight management strategies can be explored if GLP-1 agonists are not suitable for an individual patient

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Despite the potential for overlapping side effects, there are clinical scenarios where concurrent use of linaclotide and Wegovy may be considered appropriate under specialist guidance

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Your hormones shift dramatically in perimenopause

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