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Participants taking tirzepatide lost an average of 15.3% of their body weight after a year, while those on semaglutide lost about 8.3%

The search included terms such as small molecule GLP-1 receptor agonists, oral GLP-1 receptor agonists, Danuglipron, Orforglipron, and Aleniglipron. Additionally, information on ongoing clinical trials involving small molecule GLP-1 receptor agonists was retrieved from the ClinicalTrials.gov database using the same keywords