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These findings suggest that increased DPP-4 activity could indirectly foster bone resorption while hindering bone formation, thereby elevating the risk of osteoporosis

3.11 Cancer Concerns have been expressed about the effects of incretin-mimetic drugs on pancreatic tissue [157, 158]

Triple agonists add glucagon receptor activation, which: Increases resting energy expenditure by 8% to 12% (Jall et al., Diabetes Care 2024) Promotes hepatic fat oxidation and reduces steatosis May offset some of the lean mass loss seen with GLP-1 monotherapy (early signal, not yet confirmed in long-term trials) The weight loss ceiling for retatrutide appears to be 24% to 26% based on phase 3 data, though long-term real-world outcomes are not yet available

All Signos+ medications are compounded