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18 A non-infringing oral strategy might utilize different absorption enhancers or targeted release capsules that protect the peptide until it reaches a specific section of the small intestine

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Currently, there are 20 oligonucleotide drugs approved by the FDA and the European Medicines Agency (EMA) and a majority of them treat orphan and rare diseases.In 2023, FDA approved four ONTs AstraZeneca-Ionis Wainua (eplontersen), Novo Nordisk owned Dicerna Pharmaceuticals Rivfloza (nedosiran), Biogen-Ionis Qalsody (tofersen) and Iveric Bios Izervay (avacincaptad pegol).In 2021, the global ONT market size was estimated to be US$ 18.2 billion

coli levels in mice via sympathetic nervous system activation, as well as attenuating tight junction gene expression in the caecum of DSS colitis mice and, hence, promoting bacterial translocation [26]