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However, in juvenile but not adult human islets, exendin-4 stimulated calcineurin/NFAT signaling and enhanced expression of proliferation-promoting factors such as NFATC1, FOXM1, and CCNA1 [557]

For example, one clinical trial reported that 15.2 percent of participants experienced headaches after higher-dose semaglutide, compared to 12.2 percent of participants receiving a placebo (an inactive treatment)

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