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Especially around regenerative models, muscle signaling, and metabolic pathways tied to GLPs

But this year, doctors might prescribe more than just diet and exercise.

Enter novel therapeutics like CCT217: By driving beige fat activation and functional thermogenesis, these agents could rapidly improve insulin sensitivity, ApoB/TG, hsCRP, hepatic fat, and microvascular functioneven before the scale moves

At the same time, payer policies often require discontinuation of GLP-1 therapy when a patients BMI drops below a set threshold, inadvertently triggering a frustrating cycle of weight loss and regainthe so-called yo-yo effect. This not only impacts ongoing adherence and persistence but also undermines the long-term cost-effectiveness of these therapies for healthcare systems