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B.da Costa MelloS.ReichardtK.Dourado-NetoD

Powerful antioxidant for cellular defense

82 Besides, drug-induced ROS can inhibit the PI3K/AKT pathway to suppress cancer cell proliferation by disrupting key pathways critical for tumor growth and survival, as evidenced by studies with (+)-anthrabenzoxocinone in NSCLC and 6-methoxydihydrosanguinarine in breast cancer

These findings highlight the mucoadhesive nature of chitosan as a key factor in prolonging the residence time of nanoparticles at the absorption site, thereby facilitating improved drug permeation and absorption