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BPC-157 may enhance fibroblast activity, support collagen synthesis, influence angiogenesis, and upregulate skeletal muscle protein synthesis, making it effective for healing musculoskeletal injuries

A separate line of investigation, work by Pollard and colleagues, demonstrated that GHK-Cu could reverse detrimental changes in irradiated cultured human fibroblasts: cells exposed to significant radiation and then treated with GHK-Cu at very low concentrations displayed a growth pattern and growth-factor secretion profile comparable to non-irradiated control cells, including increased secretion of bFGF and VEGF

Similarly, Berberine has been shown to inhibit CYP2D6 and CYP3A4, which can increase the risk of drug accumulation and toxicity when co-administered with tricyclic antidepressants, macrolide antibiotics, or calcium channel blockers