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2017 meta-analysis: A systematic review and meta-analysis of nine randomized controlled trials showed that ALCAR supplementation significantly decreased depressive symptoms compared to placebo (standardized mean difference 1.10, 95% CI 1.65 to 0.56), with effects comparable to established antidepressants like fluoxetine, particularly in older adults or those with treatment-resistant depression [5][30]

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Moreover, another study indicated that the following a diet with high omega-3 and low omega-6 fatty acids in comparison to a diet with low omega-6 had desirable effects on pain, quality of life, and antinociceptive lipid mediators in migraine patients (136)

Targeting metabolism in aortic aneurysm and dissection: from basic research to clinical applications