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Another study showed that a bartoldine derivative, DMMOCPTL, binds directly to selenosecysteine 46 of GPX4, resulting in ubiquitination of GPX4 in triple-negative breast cancer cells (Ding et al., 2021)
the transmembrane domain (TMD), which forms the ion channel within the plasma membrane
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Science 290:13641368 [PubMed] [Google Scholar] Faure S, Chapot R, Tallet D, Javellaud J, Achard JM, Oudart N
