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It can be challenging for some people to acquire an optimal dietary intake of ascorbate, particularly in those with factors that increase requirements

This linkage of Prx2 to the membrane appears to be through the N-terminal cytoplasmic domain of band 3, which is also the site of linkage of other cytoplasmic proteins, including metHb [98]

Other effects mentioned in the report are nausea
Optimizing such schedules to carefully balance tumor control while avoiding toxicities remains a vital area for ongoing clinical investigation