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doi:10.1093/eurheartj/ehz455 Forte F, Calcaterra I, Lupoli R, et al

Anti-oxidative, anti-inflammatory and anti-apoptotic effects of flavonols: Targeting Nrf2, NF-B and p53 pathways in neurodegeneration

Therapeutic Uses LDN has been studied in various chronic conditions involving immune dysregulation and chronic pain, including: Fibromyalgia Multiple sclerosis Crohns disease Complex regional pain syndrome Autoimmune diseases Chronic fatigue syndrome While it remains off-label due to limited large-scale clinical trials, LDN shows promise as a low-cost, well-tolerated immunomodulatory and analgesic agent346
