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New and Future Developments in Microbial Biotechnology and Bioengineering

However, the same environment carries the risk of oxidative damage, such as 8-oxo-7,8-dihydroguanine (8-oxoG) and single- or double-strand breaks, which activate base excision and other DNA repair pathways

Histone H2B on lysine 120 (H2Bub1) is an epigenetic mark generally associated with transcriptional activation, and H2Bub1 epigenetically activates the expression of SLC7A11, but p53 decreases H2Bub1 occupancy on the SLC7A11 gene regulatory region and represses the expression of SLC7A11 during ferroptosis process (Wang et al., 2019f)

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