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Although an early study by Butler et al [58] demonstrated that non-hormone-expressing endocrine cells increase only modestly in islets in type 2 diabetes, by characterising the islet maturation programme at the transcriptional level during human ontogeny, Avrahami et al [59] demonstrated that a large fraction of beta cells in type 2 diabetes undergoes dedifferentiation, characterised by de-repression of immature genes

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These conditions are addressed in my latest book, Ehlers-Danlos Syndrome: Your Eyes and EDS Updated and which conditions can be detrimental or which are merely...