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Interestingly, some ligands have a bimodal effect, activating the channel in low concentrations while inhibiting it at higher doses, as it is the case of nicotine and menthol (Karashima et al., 2009

doi: 10.3390/v14092067 16 BrownJ

These parasites transition through different morphological stages - from flagellated promastigotes within a female phlebotomine sandfly (vector) gut to non-flagellated amastigotes in host macrophages [5]

It's an extremely rare variant
