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The researchers encapsulated 2-OMe and phosphorothioate modified miR-122 with a pH-sensitive lipid, which exhibited superior activity in liver cancer cells compared to Lipofectamine 2000 due to its efficient endosomal escape mechanism (Hatakeyama et al

[DOI] [PubMed] [Google Scholar] 162.Sayin V.I., Ibrahim M.X., Larsson E., Nilsson J.A., Lindahl P., Bergo M.O

In two independent experiments utilizing different mouse strains, the AF-treated mice had a 59% and 63% decreases in worm burden compared to control mice (Table 5)

44,47 Reactive oxygen species As mentioned before, augmented glutamate levels can activate catabolic processes that are known to increase intracellular reactive oxygen species (ROS)
