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Description
AFMK is a product of MEL oxidation in reactions with oxoferryl hemoglobin, singlet oxygen, superoxide anion, and hydrogen peroxide
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doi: 10.1021/jacs.5b10341
The authors hypothesized that H 2 O 2 formation in the mitochondria results in the inactivation of ATG4, promoting ATG8 lipidation, and thus, activation of autophagy
