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Accumulation of AGEs is linked to the pathogenesis of DN, where they exacerbate microvascular complications and lead to nerve degeneration (Zhang X

More importantly, it is necessary to use conditional gene knockout, overexpression models, and cross-validation with various OA models to distinguish the causal sequence, compensatory responses, and synergistic relationships between different molecules, laying the foundation for establishing truly precise and effective intervention strategies

The search parameters included tryptic cleavage C-terminal to Lys and Arg, allowing up to two missed cleavages

However, many people suffer from Vitamin B12 deficiency due to various reasons, including poor dietary intake, absorption issues, or certain medical conditions