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ERS activates a series of cascading reaction pathways, regulating the formation of intracellular iron ions and ROS through iron metabolism, Xc-/GPX4 system (Zhao et al., 2021), lipid metabolism (Tak et al., 2022), and other ferroptosis pathways such as p62-Keap1-NRF2, p53-SAT1-ALOX15, ATG5-ATG7-NCOA4, and glutaminolysis (Lane et al., 2018), playing a dual role in ferroptosis

doi: 10.1007/s40620-019-00650-x

Many people begin to notice increased energy and mental sharpness within hours or days

Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation