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Both tumor cells and myeloid cells in tumors express arginase 1 and hydrolyze arginine [222,223,224,225,226,227,228,229]

Most of these hepatic enzyme inducers are rodent hepatocarcinogens only at doses that far exceed human exposure levels
Bansal, V

The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity
