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Without biomarkers, you cant tell a working intervention from an expensive placebo

W., Ramsey J

Affected patients experience continuous depolarization of the motor end-plate, leading to paradoxical muscle weakness, fasciculations, and profound parasympathetic overstimulation (salivation, lacrimation, urination, diarrhea)

Kadia TM, Js C, Konopleva M, Borthakur G, Pemmaraju N, Daver N, Montalban-Bravo G, Issa G, Naqvi K, Short N, Dinardo C, Bhalla K, Jabbour E, Takahashi K, Sasaki K, Kornblau S, Malla R, Pierce S, Estrov Z, Andreeff M , Garcia-Manero G, Ravandi F, and Kantarjian H