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Specifically, nerve damage caused by vitamin B12 most often affects the extremities (hands and feet)
10.1158/1535-7163.Mct-09-1173 Mol
Proline accumulation in the drought-prone leaves is associated not only with increased expression of the P5CS gene, but also with decreased expression of the proline dehydrogenase (PDH) gene encoding a proline-degrading enzyme (Kishor et al., 2005
However, the exact effect was dependent upon the type of activated glutamate receptors, lesion localization and the developmental stage (Table I)
