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Das TK, Javadzadeh A, Dey A, Sabesan P, Thberge J, Radua J, et al

Although there are many potential reasons that it might benefit the cell to tie ER protein processing to TCA cycle status for example amino acid availability, ATP supply, lipid availability, etc.the one we currently favor is the balancing of the cellular redox budget

Antioxidants drugs Cisplatin-induced auditory cell death modes including apoptosis, autophagy and ferroptosis are closely related to oxidative stress, so in preclinical studies, the antioxidant reduction pathway has been the main direction of drug development against cisplatin ototoxicity (Nan et al., 2022), and alpha-lipoic Acid (Paciello et al., 2020)