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Adipose tissue NAD + biosynthesis is required for regulating adaptive thermogenesis and whole-body energy homeostasis in mice

doi: 10.1016/j.beem.2004.03.003 55 KrassasGEPoppeKGlinoerD

While this typically does not cause significant issues, if urine production is high to eliminate a lot of excess amino acids, it can contribute to water loss and could interfere with acid-base balance