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Indeed, natural products form a cornerstone of contemporary cancer treatment, with a substantial number of clinically approved anti-cancer drugs deriving from plants, animals, microorganisms, or marine organisms ( Certain classes of natural products, such as pentacyclic triterpenoids, which include PA, possess a broad spectrum of biological activities, encompassing antioxidant, antimicrobial, anti-inflammatory, and notable anti-cancer potential, even though they may occur in low abundance naturally

Methadone was generously supplied by the National Institute on Drug Abuse (NIDA, Rockville, MD)

Choi, Imaging in oncology from the University of Texas M.D

agd L, Paszkowski T, Sikorski R, Rola R