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Moreover, sustained elevation of CORT can induce the upregulation of pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNF-), enhance microglial activation, disrupt bloodbrain barrier (BBB) integrity, and facilitate the infiltration of peripheral immune cells into the central nervous system (CNS), thereby exacerbating neuroinflammation (Hooper et al., 2018)

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In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (PubMed:27471034, PubMed:29361132) Subcellular Localization Nucleus,Chromosome Expression Tissue_Specificity: Widely expressed, mainly in actively dividing tissues (PubMed:10364231)

Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.26930(July 1994),1937519379,0021-9258 29