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The Phase 2 data showed slow titration cut GI adverse events by approximately 50% (Rosenstock et al., Lancet, 2023)
demonstrated that co-culture with MSCs prevented TNF--driven DC maturation, as indicated by the failure to upregulate MHC-II or CD86, interfered with antigen presentation, as evidenced by a decrease in CD4 + T cell proliferation and MHC complex, and impaired their migration capacity towards CCL19 by downregulating CCR7 [148]

However, regular treatments should always be managed by a qualified practitioner
