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The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice

Structural analysis suggests that LicoAs ,-unsaturated carbonyl moiety, characteristic of Michael acceptors, could modify Keap1 cysteine residues, thereby inhibiting Nrf2 ubiquitination and promoting its activation (Nakamura and Miyoshi, 2010)
