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Our identification of erastin as a compound with strong binding affinity to SLC7A11 is particularly relevant, as recent studies have established erastin as a ferroptosis inducer that inhibits SLC7A11-mediated cystine uptake [30]

A quantitative PCR was carried out in duplicate for every sample

Iida R, Yasuda T, Tsubota E, Takatsuka H, Masuyama M, Matsuki T, Kishi K (2003) M-LP, Mpv17-like protein, has a peroxisomal membrane targeting signal comprising a transmembrane domain and a positively charged loop and up-regulates expression of the manganese superoxide dismutase gene

Beyond disease onset, smoking appears to negatively influence disease course in PBC