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FoxO transcription factors regulate numerous genes coding for intra- and extracellular antioxidant proteins such as Mn-SOD and Cu,Zn-SOD, peroxiredoxin-3 and peroxiredoxin-5, mitochondrial thioredoxin (Trx2) and mitochondrial thioredoxin reductase, glutathione peroxidase 1, and selenoprotein P [143]

Biol Trace Elem Res 158(1):18 Fukunaka A, Fukada T, Bhin J, Suzuki L, Tsuzuki T, Takamine Y, Bin BH, Yoshihara T, Ichinoseki-Sekine N, Naito H, Miyatsuka T, Takamiya S, Sasaki T, Inagaki T, Kitamura T, Kajimura S, Watada H, Fujitani Y (2017) Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP- expression

Nevertheless, due to the limited sample and the lack of evidence for benefit, further researches are needed