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It has been widely accepted that early detection of renal damages is vital to prevent irreparable injuries

This flowchart demonstrates how dietary precursors are metabolised by gut bacteria, leading to the production of TMA, which is then processed by the FMO3 enzyme and eventually excreted from the body

Briefly, among the initial 2870 reports, 468 articles were retrieved for detailed evaluation, and 17 RCTs [1228] enrolling 1625 participants that fulfilled the inclusion criteria were finally analyzed
