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2024;5:280311 DOI: Received: November 14, 2023 Accepted: December 18, 2023 Published: April 25, 2024 Academic Editor: Yun-Long Wu, Xiamen University, China Lung cancer remains a leading cause of cancer-related deaths globally, and a significant number of patients are ineligible for surgery, while chemoradiotherapy often shows limited efficacy, a systemic distribution, a low drug concentration at tumor sites, severe side effects, and the emergence of drug resistance